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Head of Laboratory of Neuroinflammation
Dr. Lue, Head of Laboratory of Neuroinflammation at Sun Health Research Institute, is the principal investigator of four grant-funded research projects that study Alzheimer’s and Parkinson’s diseases. Funding agencies include National Institute of Health, Arizona Alzheimer’s Disease Consortium, Arizona Biomedical Research Commission, and Arizona Science Foundation. Trained as a neuroanatomist and electron microscopist during her Ph.D. and postdoctoral fellowship, Dr. Lue has gained expertise in cellular and molecular biology during her 15-year scientific career with Sun Health Research Institute. She had a leading role in establishing procedures for glial cell isolation in autopsied elderly human brains. She and a colleague developed this into a procedure that also isolated cells from brain blood vessels — an achievement that allows neurovascular units to be built in cell culture so that they model disease causes and mechanisms which occurred at the brain-blood interface.
Dr. Lue’s research primarily addresses the molecular basis that links inflammation in brain, microvessels and circulation with cognitive dysfunction in Alzheimer’s disease. One current project studies a special molecule (the receptor for advanced glycation endproducts, or RAGE) in angiogenesis, vessel remodeling and activation, and its early involvement in cognitive functional decline in Alzheimer’s disease. Dr. Lue also leads a project that characterizes the deficiency of brain-derived nerve growth factor in postmortem frontal cortex of patients with both Parkinson’s disease and dementia.
Phone: (623) 832-5464 (Office)
(623) 832-5616 (Laboratory)