Lih-Fen Lue


Research Professor, Arizona State University Neurodegenerative Disease Research Center

Senior Scientist
Head of Laboratory of Neuroinflammation

Dr. Lue, Head of Laboratory of Neuroinflammation at Neurodegenerative Disease Research Center (NDRC) of Biodesign Institute at Arizona State University (ASU), is trained as a neuroanatomist and electron microscopist during her Ph.D. and postdoctoral fellowship. Dr. Lue has gained expertise in cellular and molecular biology during her 15-year scientific career with Sun Health Research Institute and 7 years with Banner Sun Health Research. She is now a Research Professor at the newly established NDRC at ASU.  She had a leading role in establishing procedures for glial cell isolation in autopsied elderly human brains. She and a colleague developed this into a procedure that also isolated cells from brain blood vessels — an achievement that allows neurovascular units to be built in 3-D culture so that they model disease causes and mechanisms which occurred at the brain-blood interface.

Dr. Lue’s research primarily addresses the molecular basis that links inflammation in brain, microvessels and circulation with cognitive dysfunction in Alzheimer’s disease. Dr. Lue has also worked on research projects that characterizes the deficiency of brain-derived nerve growth factor in postmortem frontal cortex of patients with both Parkinson’s disease and dementia.  Some of her current research focuses are on the development of blood biomarkers for neurodegenerative diseases.

Phone: (480) 727-3852 (Office)

(480) 727-3851 (Laboratory)