Matthew Huentelman


Neurogenomics, TGen

Professor in the Neurogenomics Division
of the Translational Genomics Research Institute (TGen)

Dr. Huentelman, Ph.D., is a Professor in the Neurogenomics Division of the Translational Genomics Research Institute (TGen), where his research interests center around the investigation of the “-omics” (genomics, transcriptomics, and proteomics) of neurological traits and disease. His laboratory’s overarching goal is to leverage findings in these disciplines to better understand, diagnose, and treat human diseases of the nervous system. His laboratory focuses on the study of Alzheimer’s disease and aging.

The Huentelman Lab examines Alzheimer’s disease with the use of next generation DNA and RNA sequencing. They are currently examining the genomic sequence of several individuals with Alzheimer’s disease with the hope of identifying new risk factors and treatment opportunities.

Dr. Huentelman also leads the MindCrowd project, an online crowdsourcing study to help understand memory performance. Tens of thousands of people from across the nation and around the world have taken the simple, 10-minute test. Everyone 18 and older is invited to participate in this, the largest study of its kind, at

The process of aging is a developmental stage that we all must go through. Like other developmental stages our individual response to the process of aging differs dramatically from person to person. The Huentelman Lab is using genomics and transcriptomics to better understand why some individuals exhibit better cognitive aging when compared to others of the same age bracket. The hope is that through the better understanding of these differences we may someday be able to develop therapeutics that could enable a larger portion of the population to exhibit better cognitive aging.

Dr. Huentelman joined TGen in July of 2004 after completing his doctoral work at the University of Florida’s Department of Physiology and Functional Genomics at the McKnight Brain Institute where he investigated the application of gene therapy in the study of hypertension. His undergraduate degree is from Ohio University’s Department of Chemistry and Biochemistry at Clippinger Laboratories. Dr. Huentelman’s career includes visiting researcher stints in Moscow, Russia, at the MV Lomonosov Moscow State University “Biology Faculty” and in the United Kingdom within the University of Bristol’s Department of Physiology.